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Acute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortex

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dc.contributor.authorGarcía-Saldívar, Norma Lauraspa
dc.contributor.authorReyes-González-López, Maríaspa
dc.contributor.authorMonroy, Juanaspa
dc.contributor.authorDomínguez, Robertospa
dc.contributor.authorCruz-Morales, Sara Eugeniaspa
dc.date.accessioned2015-05-26T20:39:38Zspa
dc.date.available2015-05-26T20:39:38Zspa
dc.date.issued2014-07spa
dc.description.abstractThe prefrontal cortex (PFC) participates in cognitive functions and stress regulation. Noradrenaline (NA) and serotonin (5-HT) levels in some regions of the central nervous system are modified by acute stress. The effects depend on the type of stressor and the time elapsed between the presence of the stressor and the assessment. The aims of the present study were to assess the acute effect of different stressors on NA and 5-HT activities in the PFC and its relation with corticosterone levels. Independent groups of male Wistar rats (250-280 g) were submitted to restraint, footshock or training in the elevated T-maze (ETMT). The animals were sacrificed immediately (T0) or one hour (T1) after stress exposure. An untreated group sacrificed concurrently with treated animals was included as control. Samples of the PFC were dissected and the concentration of NA, 5-HT and their metabolites were measured by HPLC. Corticosterone levels were measured in serum. None of the treatments modified NA levels in the PFC. Animals exposed to footshock or ETMT showed significantly higher concentrations of 5-HT at T0. Restraint and footshock treatments were associated with higher corticosterone levels at T0 and T1 after the respective treatment. Taken together the results show that in the PFC, the noradrenergic and serotonergic systems, and the corticosterone levels respond in different ways to different stressors.spa
dc.description.abstractLa corteza prefrontal (CPF) participa en las funciones cognitivas y la regulación del estrés. Las concentraciones de noradrenalina (NA) y serotonina (5-HT) en algunas regiones en el sistema nervioso central son modificadas por el estrés agudo. El efecto depende del estresor y del tiempo que transcurra entre el estresor y la evaluación. El objetivo del presente estudio fue evaluar el efecto agudo de diferentes estresores en la actividad de la NA y 5-HT en la CPF y su relación con los niveles de corticosterona. Grupos independientes de ratas (250-270 g) fueron sometidos a restricción, choque o entrenamiento en el laberinto elevado en T (ELET). Los animales fueron sacrificados inmediatamente (T0) o una hora (T1) después de la exposición al estrés. Un grupo no tratado, sacrificado al mismo tiempo que los animales tratados, se incluyó como control. Las muestras de la CPF fueron disecadas y la concentración de NA, 5-HT y sus metabolitos fue detectada por la técnica de HPLC. Las concentraciones de corticosterona fueron medidas en el suero. Ninguno de los tratamientos modificó las concentraciones de NA en la CPF. Al T0 los animales expuestos a choque o al ELET mostraron concentraciones de 5-HT significativamente mayores que el control. Los tratamientos de restricción y choque estuvieron asociados con altas concentraciones de corticosterona al T0 y a T1 después del tratamiento respectivo. En conjunto, los resultados mostraron que en la CPF los sistemas noradrenérgico y serotonérgico y la concentración de corticosterona responden en forma diferente a los distintos estresores.spa
dc.description.abstractO córtex pré-frontal (CPF) participa nas funções cognitivas e na regulação do estresse. As concentrações de noradrenalina (NA) e serotonina (5-HT) em algumas regiões do sistema nervoso central são modificadas pelo estresse agudo. O efeito depende do estressor e do tempo que transcorra entre o estressor e a avaliação. O objetivo do presente estudo foi avaliar o efeito agudo de diferentes estressores na atividade da NA e 5-HT no PFC e sua relação com os níveis de corticosterona. Grupos independentes de ratos (250-270 g) foram submetidos a restrição, choque ou treinamento no labirinto elevado em T (ELET). Os animais foram sacrificados imediatamente (T0) ou uma hora (T1) depois da exposição ao estresse. Um grupo não tratado, sacrificado ao mesmo tempo que os animais tratados, incluiu-se como controle. As mostras do PFC foram dissecadas e a concentração de NA, 5-HT e seus metabolitos foi detectada pela técnica de HPLC. As concentrações de corticosterona foram medidas no soro. Nenhum dos tratamentos modificou as concentrações de NA no PFC. Em T0 os animais expostos a choque o ao ELET mostraram concentrações de 5-HT significativamente maiores que o controle. Os tratamentos de restrição e choque estiveram associados com altas concentrações de corticosterona em T0 e em T1 depois do tratamento respectivo. Em conjunto, os resultados mostraram que no PFC os sistemas noradrenérgico e serotonérgico e a concentração de corticosterona respondem de maneira diferente aos diferentes estressores.spa
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dc.identifier.citationGarcía-Saldívar, N., Reyes-González-López, M., Monroy, J., Domínguez, R., & Cruz-Morales, S. (2014). Acute effects of restraint, shock and training in the elevated t-maze on noradrenaline and serotonin systems of the prefrontal cortex. Acta Colombiana de Psicología, 17(2), 23-31. Recuperado de http://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/161spa
dc.identifier.issn0123-9155spa
dc.identifier.urihttp://hdl.handle.net/10983/2277spa
dc.language.isoengspa
dc.publisherUniversidad Católica de Colombia. Facultad de Psicologíaspa
dc.relation.ispartofActa Colombiana de Psicología, Vol. 17, no. 2 (jul.-dic. 2014); p. 23-31spa
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dc.rightsDerechos Reservados - Universidad Católica de Colombia, 2014spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.subjectSTRESSORSspa
dc.subjectNORADRENALINEspa
dc.subjectSEROTONINspa
dc.subjectPREFRONTAL CORTEXspa
dc.subjectCORTICOSTERON6Aspa
dc.subjectESTRESORESspa
dc.subjectNORADRENALINAspa
dc.subjectSEROTONINAspa
dc.subjectCORTEZA PREFRONTALspa
dc.subjectCORTICOSTERONAspa
dc.subjectESTRESSORESspa
dc.subjectCÓRTEX PRÉ-FRONTALspa
dc.subject.lembESTRÉS (FISIOLOGÍA)spa
dc.subject.lembNEUROTRANSMISORES-INVESTIGACIONESspa
dc.subject.lembCORTEZA CEREBRALspa
dc.subject.lembHORMONAS ADRENOCORTICALES-INVESTIGACIONESspa
dc.subject.lembPSICOLOGÍA EXPERIMENTALspa
dc.titleAcute effects of restraint, shock and training in the elevated T-Maze on noradrenaline and serotonin systems of the prefrontal cortexspa
dc.title.translatedEfectos agudos de la restricción, choque y entrenamiento en el laberinto elevado en T en los sistemas de noradrenalina y serotonina en la corteza prefrontaleng
dc.title.translatedEfeitos agudos da restrição, choque e treinamento no labirinto elevado em T nos sistemas de noradrenalina e serotonina no córtex pré-frontaleng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
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dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
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