Título : Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar
Otros títulos : Effects of electrical stimulation of the habenula on the modulation of emotional responses in Wistar rats
Efeitos da estimulação elétrica habenular na modulação de respostas emocionais em ratos Wistar
Autores : Herrera, María Laura
Guisselle Rubio, Natalia
Quintanilla, Juan Pablo
Huerta, Víctor Manuel
Osorio Forero, Alejandro
Cárdenas Molano, Melissa Andre
Corredor Páez, Karen
Valderrama, Mario
Cárdenas, Fernando
Palabras clave: COMPORTAMIENTO EMOCIONAL
ESTIMULACIÓN ELÉCTRICA CEREBRAL PROFUNDA
HABÉNULA
RATAS
DEEP BRAIN STIMULATION
EMOTIONAL BEHAVIOR
HABENULA
RATS
COMPORTAMENTO EMOCIONAL
ESTIMULAÇÃO ELÉTRICA CEREBRAL PROFUNDA
HABÊNULA
RATOS
Fecha de publicación : jul-2018
Editor: Universidad Católica de Colombia. Facultad de Psicología
Citación : Herrera, M., Rubio, N., Quintanilla, J., Huerta, V., Osorio-Forero, A., Cárdenas Molano, M., Corredor Páez, K., Valderrama, M., & Cárdenas, F. (2018). Efectos de la estimulación eléctrica habenular en la modulación de respuestas emocionales en ratas Wistar. Acta Colombiana de Psicología, 21(2), 212-235. Recuperado de https://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/1455
Resumen : A pesar del amplio uso de la estimulación cerebral profunda para controlar patologías neurológicas y neuropsiquiátricas, su mecanismo de acción aún no es claramente conocido, y existen pocos estudios sistemáticos que relacionen la variación de parámetros de estimulación eléctrica (frecuencia, intensidad, duración del pulso) y la ejecución comportamental. La habénula es una estructura reguladora de respuestas emocionales diana en tratamientos para dolor crónico y depresión, pero la relación entre su estimulación crónica y el desempeño animal en pruebas conductuales no se ha establecido con claridad. Con el objetivo de evaluar el efecto emocional de la estimulación habenular crónica, en este estudio se utilizaron ratas Wistar que recibieron estimulación habenular a intensidad baja (10-80 pA) o alta (120-260 pA) y frecuencia baja (80-150 Hz) o alta (240380 Hz): BIBF-AIBF-BIAF-AIAF, durante 15 minutos a lo largo de tres días consecutivos. Al cuarto día, se hizo la evaluación en un laberinto elevado en cruz y en campo abierto. Los resultados indican un efecto de tipo ansiolítico en el tratamiento BIAF, en comparación con BIBF y AIBF (aumento del número de entradas, porcentaje de tiempo en brazos abiertos y de la distancia recorrida en ellos), efecto que no se explica por cambios en la locomotricidad (distancia recorrida en los brazos cerrados y la exploración en el campo abierto). Se concluye que el parámetro frecuencia posee mayor impacto sobre el efecto comportamental que la intensidad -lo que puede explicar algunos hallazgos paradójicos previos-, que los parámetros utilizados no poseen efecto ansiogénico, y que los efectos potencialmente ansiogénicos de la estimulación a baja frecuencia y el papel de los sistemas dopaminérgicos y serotoninérgicos encontrados deben ser estudiados en futuras investigaciones.
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URI : https://hdl.handle.net/10983/22342
ISSN : 0123-9155
Es parte de: Acta Colombiana de Psicología, Vol. 21 no. 2 (jul.-dic. 2018); p. 212-235
Aparece en las colecciones: CAA. Acta Colombiana de Psicología

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