Title: Effects of CB1 Cannabinoid Receptor activation in the nucleus Accumbens Shell on feeding behavior
Other Titles: Efectos de la activación del receptor cannabinoide CB1 en el núcleo Accumbens Shell sobre la conducta alimentaria
Efeitos da ativação do receptor cannabinóide CB1 no núcleo Accumbens Shell sobre a conduta alimentar
Authors: Cortés-Salazar, Felipe
Suárez Ortíz, Josué Omar
Mancilla-Díaz, Juan Manuel
Cendejas Trejo, Nancy Mónica
López-Alonso, Verónica Elsa
Escartín-Pérez, Rodrigo Erick
Keywords: CANNABINOIDS
FOOD
NUCLEUS ACCUMBENS SHELL
BEHAVIORAL SATIETY SEQUENCE CANABINOIDES
ALIMENTACIÓN
NÚCLEO ACCUMBENS SHELL
SECUENCIA DE SACIEDAD CONDUCTUAL
CANABINÓIDES
ALIMENTAÇÃO
NÚCLEO ACCUMBENS SHELL
SEQUÊNCIA DE SACIEDADE CONDUCTUAL
OBESIDAD-TRATAMIENTO
OBESIDAD-ASPECTOS PSICOLÓGICOS
CANNABIS
FARMACOLOGÍA
TRASTORNOS DE LA NUTRICIÓN
Issue Date: Jul-2014
Publisher: Universidad Católica de Colombia. Facultad de Psicología
Citation: Cortés-Salazar, F., Suárez Ortíz, J., Cendejas Trejo, N., Mancilla-Díaz, J., López-Alonso, V., & Escartín-Pérez, R. (2014). Effects of CB1 cannabinoid receptor activation in the nucleos accumbens shell on feeding behavior.Acta Colombiana de Psicología, 17(2), 61-68. Recuperado de http://editorial.ucatolica.edu.co/ojsucatolica/revistas_ucatolica/index.php/acta-colombiana-psicologia/article/view/165
Abstract: La obesidad y sus patologías relacionadas son riesgos de salud muy conocidos. Aunque la obesidad y el sobrepeso tienen causas multifactoriales, la sobreingesta de alimento es frecuente en estas condiciones. De acuerdo con modelos animales, los endocanabinoides y sus receptores en el cerebro juegan un papel clave en la génesis y desarrollo de la obesidad. Se ha propuesto que los receptores a canabinoides CB1 (RCB1) expresados en el núcleo accumbens shell (NAcS) están involucrados en el incremento de las propiedades hedónicas del alimento. Para probar esta hipótesis, este estudio tuvo como objetivo evaluar los efectos de la activación de los RCB1 en el NAcS sobre la ingesta de alimento estándar durante la fase de luz del ciclo luz-oscuridad. Se evaluaron los efectos de la activación de los RCB1 con WIN 55-212-2 y CP 55,940 (0.125, 0.25, y 0.5 nmol) en el NAcS sobre la conducta alimentaria y la secuencia de saciedad conductual en ratas. Se encontró que ambos agonistas aumentaron la ingesta de alimento y demoraron la expresión de la saciedad durante la fase de luz. Lo anterior sugiere que los agonistas canabinoides estimulan el consumo de alimento cuando la motivación por el mismo es baja y la palatabilidad es normal.
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URI: http://hdl.handle.net/10983/2281
ISSN: 0123-9155
metadata.dc.relation.ispartof: Acta Colombiana de Psicología, Vol. 17, no. 2 (jul.-dic. 2014); p. 61-68
Appears in Collections:Acta Colombiana de Psicología

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